Resumen
Con el objetivo de conocer la evolución de los pacientes con colestasis neonatal respecto a las diferentes etiologías, se realizó un estudio descriptivo de 91 pacientes diagnosticados de colestasis neonatal en el Servicio de Pediatría del Hospital Universitario «Reina Sofía» entre los años 2002 y 2007. Los datos se extrajeron de las historias clínicas de los pacientes. En 2007 los niños fueron citados para una entrevista, en la que se realizaron una anamnesis, un examen físico y estudios analíticos. Los datos se registraron en fichas codificadas, que se analizaron con el programa SSPS. Se analizaron y describieron las etiologías encontradas, así como la evolución clínica de los pacientes. La evolución fue similar a la descrita en otras series, excepto en el caso de los niños trasplantados, que tuvieron una peor evolución, y en los casos de hepatitis neonatal, en que todos, excepto uno, presentaron una buena evolución, probablemente porque varios correspondían a hepatitis neonatales transitorias.
Abstract
A descriptive study was conducted to determine the disease course in patients with a history of neonatal cholestasis with regard to a number of conditions, and to compare it with that observed in children at other centers. The children enrolled had been diagnosed in the Department of Pediatrics of Reina Sofía University Hospital. Data were drawn from pre-coded cards, completed when the patients were seen for the first time, and from their clinical records. Appointments were arranged for the children in which their clinical case and the results of physical examination and lab testing were recorded in coded cards. Data were analyzed using the SSPS software package. Neonatal cholestasis was diagnosed in 91 children from 2002 to 2007. The etiologies, clinical course and laboratory testing are discussed and described. The disease course was similar to that described in other series, except in transplanted children, who had a poorer course, and in the cases of neonatal hepatitis, all of which had a favorable course, probably because several of these patients had transient neonatal hepatitis. Referral to tertiary care was typically late and should be especially addressed in continuing medical education activities.
Original_Colestasis.pdf
