Información adicional

• Num_publicacion 72(3)
• Resumen_ingles

  Introduction: The prognosis of autoimmune hepatitis (AIH) depends on the diagnosis and early treatment. However, specific diagnosis markers remain unknown. The international group for the AIH created a diagnostic score, but there is uncertainty about its validity in paediatrics.
  Purpose: Analysis of the diagnostic ability of the score between 0 and 23 years old.
  Patients and methods: Retrospective study (February 1994-December 2010) of 0 to 23 year-old patients diagnosed of AIH according to clinical, laboratory, serological and pathological findings. The score is applied pre and post-treatment.
  Results: 10 patients were included. Pre-treatment AIH score diagnoses "definitive" in 3 patients, "probable" in 5 and "exclusion" in 2. Replacement of cholestasis marker "alkaline phosphatase" (AP) by "gamma-glutamyl-transferase" (GGT) alters the classification of 2 patients with "probable" to "definitive", and "exclusion" to "probable" sense. Removal of the indicator "alcohol" does not induce changes. The post-treatment AIH score diagnoses "definitive" in 6 patients and "probable" in 4, with no changes inducing the elimination of the "alcohol" marker and as do replacing AF by GGT (1 patients with variation from "probable" to "definitive").
  Conclusions: All patients responded to immunosuppressive agents steadily and did not develop cholestasis. This supports the diagnosis of AIH regardless of the score. The score should be cautiously interpreted because it does not allow any diagnostic exclusion, with superior value post-treatment. The replacement of "AP" indicator for "GGT" should be considered.

• Palabras_clave_ingles Sclerosing cholangitis Alcaline phosphatase Gamma glutamyil transferase Autoimmune hepatitis Score
• Todos_autores C. Navarro Moreno¹, M. Navarro Paterna2, S. Negre Policarpo², A. Pereda Pérez³
• autores listados C. Navarro Moreno, M. Navarro Paterna, S. Negre Policarpo, A. Pereda Pérez
• Correspondecia
  C. Navarro Moreno. Servicio de Pediatría. Hospital Universitario de Fuenlabrada. Camino del Molino, 2. 28942 Fuenlabrada (Madrid).
  Correo electrónico: constanza.navarro@salud.madrid.org
• Titulo_ingles Implementation of diagnosis of autoimmune hepatitis score in pediatrics: long-term review
• Centros_trabajo ¹Servicio de Pediatría. Hospital Universitario de Fuenlabrada. Madrid. ²Unidad de Pediatría Integral Q Valencia. Hospital Quirón. ³Unidad de Gastroenterología Infantil. Hospital Universitario «La Fe». Valencia
• Publicado en Acta Pediatr Esp. 2014; 72(3): e94-e99
• copyright ©2014 Ediciones Mayo, S.A.
• Fecha recepcion 14/05/12
• Fecha aceptacion 25/09/12