Información adicional

• Num_publicacion 70(10)
• Resumen_ingles

  Background and objectives: The subcutaneous G immunoglobulin therapy (SCIg) is a common alternative to intravenous therapy (IVIg) in the treatment of humoral immunodeficiencies in many countries. We present the largest clinical experience with this type of therapy in a tertiary hospital in Spain. The two main techniques for subcutaneous administration are also analized: pump therapy, or infusion by pump, and push therapy, or manual infusion, emphasizing that there is no previous experience with the latter in our country.

  Patients and methods: A retrospective study was performed of the patients in SCIg therapy during the first two years after the establishment of the therapy in our center, following a protocol based in SCIg weekly doses equal to monthly IVIg doses, analyzing efficacy, security and costs.

  Results: 13 patients were recluted, 8 of them males, with a median age of 18, and the most frequent primary disease was CVID (9/13). SCIg therapy resulted in 37% higher seric gammaglobulin trough levels, while the infection rate remained low, most of them mild infections No systemic adverse events were registered, although local reactions where very common but mild and transient. The most commonly used technique was push therapy, which was more economic than pump therapy.

  Conclusions: The subcutaneous IgG replacement therapy has been satisfactorily established in our center, obtaining good results in efficacy and safety. Regarding our experience, the manual technique or push therapy has several advantages compared to the pump therapy that makes it preferable for the daily clinical practice, although larger series, randomized controlled trials are necessary.

• Palabras_clave_ingles Subcutaneous immunoglobulin humoral immunodeficiencies pump infusion manual subcutaneous infusion
• Todos_autores P. García Casas¹, L.I. González-Granado²
• autores listados P. García Casas, L.I. González-Granado
• Correspondecia
  P. García Casas. Unidad de Inmunodeficiencias. Servicio de Pediatría. Hospital Universitario «12 de Octubre». Ctra. de Andalucía, km 5,4. 28041 Madrid.
  Correo electrónico: paula.garciacasas@gmail.com
• Titulo_ingles Experience with subcutaneous G immunoglobulin in antibody deficiencies
• Centros_trabajo ¹Unidad de Inmunodeficiencias. Servicio de Pediatría. Hospital Clínico «San Carlos». ²Unidad de Inmunodeficiencias. Servicio de Pediatría. Hospital Universitario «12 de Octubre». Madrid
• Publicado en Acta Pediatr Esp. 2012; 70(10): 385-391
• copyright ©2012 Ediciones Mayo, S.A.
• Fecha recepcion 12/08/11
• Fecha aceptacion 12/09/11