Información adicional
- Num_publicacion 78(1-2)
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Resumen_ingles
Introduction: Non-pharmacological therapies in the treatment of allergic rhinitis (AR) are of great importance, particularly in children. The adjuvant use of nasal irrigations helps eliminate potential allergens and mucus and may improve the symptoms of rhinitis.
Material and methods: Pilot study, multicenter, randomized (2:1) and controlled with placebo, on the use of an inhaler with 0.2% hyaluronic acid, dexpanthenol and xanthan gum vs non-use of the inhaler to relieve nasal congestion in pediatric patients with AR, with 45 day follow-up.
Results: 80 patients between 6 and 11 years old were included 51 in the study group and 29 in the control group). Nasal congestion and difficulty breathing only decreased significantly (p <0.0001) in the study group. Rhinorrhea and frequency of sneezing improved in both groups (p <0.05). However mouth breathing, sneezing intensity, nasal and pharyngeal itching, anosmia and eye symptoms only improved with the use of the inhaler. In the daily record of the parents during the first and third week, the symptoms of AR only decreased significantly in the study group (p <0.0001). At the end of the study, the physician’s Global Clinical Impression was improvement in 93.9% of the subjects in the study group compared to 52.4% in the control group.
Conclusions: Compared to the usual treatment the use of the inhaler with a mucosal protective film as an adjuvant measure, contributes to a significant improvement in the symptoms of AR, including the accompanying ocular symptoms. - Palabras_clave_ingles Allergic rhinitis nasal congestion inhaler hyaluronic acid dexpanthenol xanthan gum
- Todos_autores C. Crespo Mora1, L. López Granados2, E.M. Pacheco3, F. Valle4, J. Molina5, M.J. Llobera5, C. Ferrer6, C. García Peláez5
- autores listados C. Crespo Mora, L. López Granados, E.M. Pacheco, F. Valle, J. Molina, M.J. Llobera, C. Ferrer, C. García Peláez
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Correspondecia
C. Crespo Mora. CAP Montclar. Sant Boi de Llobregat (Barcelona). Correo electrónico: ccrespo@ambitcp.catsalut.net
- Titulo_ingles Effectiveness of a specific descongestionant inhaler with protective film in the management of allergic rhintis. A multi-centre, randomized, controlled study
- Centros_trabajo 1CAP Montclar. Sant Boi de Llobregat (Barcelona). 2CAP Sant Andreu. Sant Andreu de la Barca (Barcelona). 3CS Mossèn Cinto Verdaguer. L’Hospitalet de Llobregat (Barcelona). 4CAP Sant Just. Sant Just Desvern (Barcelona). 5CAP Maria Bernades. Viladecans (Barcelona). 6Centre CASBE. Barcelona
- Publicado en Acta Pediatr Esp. 2020; 78(1-2): 6-13
- copyright ©2020 Ediciones Mayo, S.A.
- Fecha recepcion 11/07/19
- Fecha aceptacion 21/11/19
- Tipo de Artículo Clínico (Microdatos) Multicenter Study
Información adicional
- Num_publicacion 76(11-12)
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Resumen_ingles
Background: Persistent congestive nasal symptoms have a negative influence on patients’ quality of life, daily activities and sleep. The current available treatments are partly effective, and it would be desirable to develop products which help to relieve these symptoms. The purpose of this study was to research into the effectiveness and safety of a nasal spray with hyaluronic acid in children.Methods: This was a pilot, prospective, multicentric, uncontrolled study with a 0.2% hyaluronic acid nasal spray, tested in children aged from 2 to 11 with nasal congestion. The spray was used for 7 days, with two visits, basal (day 0) and final (day 7), and a daily record of symptoms by parents. Effectiveness, safety, ease of use and users’ satisfaction were assessed.Results: 99 patients were included. Statistically significant improvements (p <0.001) were observed in the parameters studied between basal and final visits, and at the third and sixth day: nasal congestion, difficulty in breathing through the nose, runny nose, breathing through the mouth during the day and during the night, and difficulty in sleeping, eating and performing physical activities. Satisfaction of users and researchers was greater than 80%.Conclusions: The nasal spray with hyaluronic acid had high effectiveness and safety in children with nasal congestion symptoms, and was evaluated very positively by researchers, parents and children older than 8.
- Palabras_clave_ingles Nasal congestion Nasal spray Hyaluronic acid Primary care
- Todos_autores M.Á. Giménez Abián1, C. Crespo Mora2, I. Ferriz Vidal3, G. Esquinas Rychen4, G. Ricós Furió5, A. Fernández Feijoo6, E.M. Pacheco Navas6, J. Martí Fernández7, E. Redondo Gorostiza2, N. Freixenet Guitart8
- autores listados M.Á. Giménez Abián, C. Crespo Mora, I. Ferriz Vidal, G. Esquinas Rychen, G. Ricós Furió, A. Fernández Feijoo, E.M. Pacheco Navas, J. Martí Fernández, E. Redondo Gorostiza, N. Freixenet Guitart
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Correspondecia
M.Á. Giménez Abián. Fernández Caballero, 42. 28660 Boadilla del Monte (Madrid).
Correo electrónico: mariaangeles.gimenez@salud.madrid.org
Financiación: Pharmalink S.L.
Conflicto de intereses: Los participantes en el estudio han recibido un pago por el Promotor a través de la Fundación para la Investigación e Innovación Biomédica de Atención Primaria de la Comunidad de Madrid. Dicha cantidad no ha constituido en ningún caso una obligación o inducción al Centro, la Fundación y/o los investigadores para recomendar, prescribir, comprar, usar o concertar el uso de ningún producto del Promotor (Pharmalink S.L.). - Titulo_ingles Pilot study of safety and decongestant efficacy of 0.2% hyaluronic acid
- Centros_trabajo Pediatras de Atención Primaria. 1CS Condes de Barcelona. Boadilla del Monte (Madrid). 2CAP Montclar. Sant Boi de Llobregat (Barcelona). 3CS Valdelasfuentes. Alcobendas (Madrid). 4CAP Baix Ebre. Tortosa (Tarragona). 5CAP Drassanes. Barcelona. 6CAP Mossen Cinto Verdaguer. L’Hospitalet de Llobregat (Barcelona). 7CAP La Marina. Barcelona. 8CAP Corbera de Llobregat. Corbera de Llobregat (Barcelona)
- Publicado en Acta Pediatr Esp. 2018; 76(11-12): 147-155
- copyright ©2018 Ediciones Mayo, S.A.
- Fecha recepcion 27/07/17
- Fecha aceptacion 30/11/17
- Tipo de Artículo Clínico (Microdatos) Observational Study
